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ATM Inhibitor-3

CAT: 0804-HY-144686Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144686Size:1 Each
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Description
ATM Inhibitor-3 (compound 34) is a potent and selective ATM inhibitor, with an IC50 of 0.71 nM. ATM Inhibitor-3 shows inhibition of PI3K kinases family. ATM Inhibitor-3 exhibits favorable metabolic stability[1].
CAS Number
2769140-52-3
UNSPSC
12352005
Target
ATM/ATR; mTOR; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
COCCN1C(N(C2=C1C3=CC(C4=CC(F)=C(C=C4)NC(NCCN(C)C)=O)=CC=C3N=C2)C)=O
Molecular Formula
C25H29FN6O3
Molecular Weight
480.53
References & Citations
[1]Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; mTOR; PI3K

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