HE-S2

HE-S2

• CAS Number: 2939851-67-7
• UNSPSC Description: HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity[1].
• Target Antigen: Drug-Linker Conjugates for ADC; PD-1/PD-L1; Toll-like Receptor (TLR)
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/he-s2.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@H](COC(NC1=CC=C(C[N+](C)(C)CC2=CC=C(CC3=CC=C(N=C(N)N=C4NCCCC)C4=N3)C=C2)C=C1)=O)SSC5=NC=C([N+]([O-])=O)C=C5.[H]C([O-])=O
• Molecular Weight: 787.95
• References & Citations: [1]He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64(21):15716-15726.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported