HE-S2

• Description :

  HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity[1].

• UNSPSC :

  12352203

• Target :

  Drug-Linker Conjugates for ADC; PD-1/PD-L1; Toll-like Receptor (TLR)

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/he-s2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@H](COC(NC1=CC=C(C[N+](C)(C)CC2=CC=C(CC3=CC=C(N=C(N)N=C4NCCCC)C4=N3)C=C2)C=C1)=O)SSC5=NC=C([N+]([O-])=O)C=C5.[H]C([O-])=O

• Molecular Formula :

  C38H45N9O6S2

• Molecular Weight :

  787.95

• References & Citations :

  [1]He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64 (21) :15716-15726.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [2939851-67-7]