HF51116

CAT: 0804-HY-144347Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-144347Size:1 Each

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Description

HF51116 is a potent antagonist of CXCR4. HF51116 strongly antagonizes SDF-1α-induced cell migration, calcium mobilization, and CXCR4 internalization. HF51116 inhibits HIV-1 infection via CXCR4. HF51116 has the potential for the research of HIV-1 infection, hematopoietic stem cell mobilization, and cancer metastasis[1].

CAS Number

2177311-29-2

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/hf51116.html

Solubility

10 mM in DMSO

Smiles

N=C(N)NCCC[C@H](NCC1=CC=CC=N1)C(NCC2=CC=C(C=C2)CNCCCNC3CCCCC3)=O

Molecular Formula

C29H46N8O

Molecular Weight

522.73

References & Citations

[1]Fang X, et al. A fragment integrational approach to GPCR inhibition: Identification of a high affinity small molecule CXCR4 antagonist. Eur J Med Chem. 2022;231:114150.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
GTR19184971-01	HF51116

HF51116

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