Cas9-IN-2

• Description :

  Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

• UNSPSC :

  12352005

• Target :

  Bacterial; CRISPR/Cas9

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/cas9-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(NC1=NOC(C)=C1)(C2=C(C)N(C(C3=NC(C)=C(C(N4CCC(CC4)C)=O)S3)=C2)C)=O

• Molecular Formula :

  C21H27N5O4S2

• Molecular Weight :

  477.60

• References & Citations :

  [1]Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65 (4) :3266-3305.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1030133-34-6]