LG308

CAT: 0804-HY-143660Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-143660Size:1 Each

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Description

LG308 is a novel synthetic compound with antimicrotubule activity. LG308 induces mitotic phase arrest and inhibits G2/M progression significantly which is associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2. LG308 also induces apoptosis and cell death. LG308 significantly suppresses tumor growth. LG308 with antimitotic activity has the potential for the research of prostate cancer[1].

CAS Number

1428341-65-4

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lg308.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=CC2=C1NC3=C2CCN(C(CC4=CC=CC=C4)=O)C3

Molecular Formula

C19H17FN2O

Molecular Weight

308.35

References & Citations

[1]Qin M, et al. LG308, a Novel Synthetic Compound with Antimicrotubule Activity in Prostate Cancer Cells, Exerts Effective Antitumor Activity. J Pharmacol Exp Ther. 2015;355 (3) :473-483.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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