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SH498

CAT: 0804-HY-143658Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143658Size:1 Each
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Description
SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.
CAS Number
2125724-38-9
UNSPSC
12352005
Target
Autophagy; BMI1
Type
Reference compound
Related Pathways
Autophagy; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sh498.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C=C1CCC2C3(C)C)=C(OC)C=C1[C@@]2(C)C=C(C#N)C3=O)NC4=CC=CC(OC(F)(F)F)=C4
Molecular Formula
C27H25F3N2O4
Molecular Weight
498.49
References & Citations
[1]Yang LF, et al. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. ACS Med Chem Lett. 2018 Sep 27;9 (11) :1105-1110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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