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Antioxidant agent-5

CAT: 0804-HY-143243Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143243Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein) -induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].
CAS Number
2684291-60-7
UNSPSC
12352005
Target
Apoptosis; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/antioxidant-agent-5.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(C=C1)CN2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C45)=N3
Molecular Formula
C24H24N6O
Molecular Weight
412.49
References & Citations
[1]Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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