UNC6349 (Ket2)

• Description :

  UNC6349 (Ket2), a diethyllysine (Ket2) -containing ligand, binds to wild-type CBX5, with a KD of 3.2 μM[1].

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/unc6349-ket2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=COC=C1)NC(C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C(OC)=C2)OC)C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCCCN(CC)CC)=O)=O)=O)C(C3=CC=CC=C3)O

• Molecular Formula :

  C41H57N7O11

• Molecular Weight :

  823.93

• References & Citations :

  [1]Kean KM, et al. Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. J Med Chem. 2022;65 (3) :2646-2655.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported