Glucocorticoid receptor-IN-2

• UNSPSC Description:

  Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC50 of 0.171 nM against hMMP1, and comparable transcriptional activation activity with an EC50 of 0.94 nM against MMTV[1].

• Target Antigen:

  Glucocorticoid Receptor; MMP

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/glucocorticoid-receptor-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=C5)C5=C2)=O

• Molecular Weight:

  512.46

• References & Citations:

  [1]Sheng Su, et al. Benzopyrazole compound. WO2021136429.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2664932-65-2