Fluocortolone

• Description:

  Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg) [1].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H320

• Target:

  Glucocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/fluocortolone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@](C[C@H]([C@@H]2C(CO)=O)C)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C([C@H](C3)F)=CC(C=C4)=O)C

• Molecular Formula:

  C22H29FO4

• Molecular Weight:

  376.46

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Bhargava A S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, et al. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, 1971, 3 (1) : 83-91. .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  152-97-6