N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride)

N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride)

• CAS Number: 2107273-00-5
• UNSPSC Description: N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/n-ac-peg3-n-azide-peg3-cy7-chloride.html
• Solubility: 10 mM in DMSO
• Smiles: CC1(C)C(/C=C/C=C/C=C/C=C2N(CCOCCOCCOCCN=[N+]=[N-])C3=C(C=CC=C3)C/2(C)C)=[N+](CCOCCOCCOC(C)=O)C4=C1C=CC=C4.[Cl-]
• Molecular Weight: 792.40
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported