N-(Mal-PEG6)-N-bis(PEG7-TCO)

• UNSPSC Description:

  N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n-mal-peg6-n-bis-peg7-tco.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCC(NCCOCCOCCOCCN(C(CCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O)=O)CCOCCOCCOCCNC(CCOCCOCCOCCOCCNC(OC3CC/C=C\CCC3)=O)=O)=O

• Molecular Weight:

  1652.95

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2093152-84-0