N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester)

• UNSPSC Description:

  N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n-azido-peg3-n-bis-peg1-t-butyl-ester.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O

• Molecular Weight:

  576.68

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2086689-00-9