2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane

• CAS Number: 2086689-05-4
• UNSPSC Description: 2-Azido-PEG3-amido-13-biscarboxylethoxypropane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-(Azido-PEG3-amido)-1,3-bis(carboxylethoxy)propane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2-azido-peg3-amido-1-3-bis-carboxylethoxy-propane.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)CCOCC(COCCC(O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O
• Molecular Weight: 464.47
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported