BCN-PEG3-VC-PFP ester

BCN-PEG3-VC-PFP ester

• CAS Number: 2353409-45-5
• UNSPSC Description: BCN-PEG3-VC-PFP ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-VC-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcn-peg3-vc-pfp-ester.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(OC(C(F)=C(F)C(F)=C1F)=C1F)=O)=O)=O)OC[C@@H]2[C@@]3([H])[C@]2([H])CCC#CCC3
• Molecular Weight: 819.81
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported