BCN-PEG3-VC-PFP ester

• Description:

  BCN-PEG3-VC-PFP ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. BCN-PEG3-VC-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC:

  12352203

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcn-peg3-vc-pfp-ester.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (NCCOCCOCCOCCC (N[C@@H] (C (C) C) C (N[C@@H] (CCCNC (N) =O) C (OC (C (F) =C (F) C (F) =C1F) =C1F) =O) =O) =O) OC[C@@H]2[C@@]3 ([H]) [C@]2 ([H]) CCC#CCC3

• Molecular Formula:

  C37H50F5N5O10

• Molecular Weight:

  819.81

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Cleavable Linker; Protease Cleavable Linker

• CAS Number:

  2353409-45-5