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HTrkA-IN-2

CAT: 0804-HY-139871Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139871Size:1 Each
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Description
HTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC50 value of 3.9 nM.
CAS Number
2986533-14-4
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/htrka-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(C2=CC=CC=C2)N=C3N1C=CN=C3C)NCC4=C(OC(F)(F)F)C=CC(COC)=C4
Molecular Formula
C24H22F3N5O3
Molecular Weight
485.46
References & Citations
[1]Subramanian G, et al. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain. ACS Med Chem Lett. 2021 Oct 25;12 (11) :1847-1852.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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