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Ten01

CAT: 0804-HY-139649Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139649Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ten01 has 5.0 nM activity against JAK1 kinase.
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ten01.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CN=C(NC=C2)C2=C1C[C@H]3CN(C(NCC(F)(F)F)=O)C[C@@H]3CC
Molecular Formula
C18H20F6N4O
Molecular Weight
422.37
References & Citations
[1]Yu Y, et al. A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors. ACS Omega. 2021 Aug 24;6 (35) :22945-22954.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK1

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