Ropanicant

CAT: 0804-HY-139581Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-139581Size:1 Each

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Description

Ropanicant (SUVN-911 free base) is a novel, potent, selective, and orally active neuronal nicotinic acetylcholine α4β2 receptor antagonist for the research of depression[1].

CAS Number

2414674-70-5

Product Name Alternative

SUVN-911 (free base)

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ropanicant.html

Solubility

10 mM in DMSO

Smiles

ClC1=NC=C(C=C1)OC[C@@H]2C[C@]3([H])[C@@](N2)([H])C3

Molecular Formula

C11H13ClN2O

Molecular Weight

224.69

References & Citations

[1]Nirogi R, Mohammed AR, Shinde AK, Ravella SR, Bogaraju N, Subramanian R, Mekala VR, Palacharla RC, Muddana N, Thentu JB, Bhyrapuneni G, Abraham R, Jasti V. Discovery and Development of 3- (6-Chloropyridine-3-yloxymethyl) -2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911) : A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63 (6) :2833-2853.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

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