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1,6-Bis (mesyloxy) hexane

CAT: 0804-HY-138327-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138327-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
16-Bismesyloxyhexane is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
CAS Number
4239-24-1
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-6-bis-mesyloxy-hexane.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
CS(=O)(OCCCCCCOS(C)(=O)=O)=O
Molecular Formula
C8H18O6S2
Molecular Weight
274.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker

Chemical Information

1,6-Hexanediol, dimethanesulfonate
CAS Number4239-24-1
PubChem CID145735
IUPAC Name6-methylsulfonyloxyhexyl methanesulfonate
Molecular FormulaC8H18O6S2
Molecular Weight274.4
XLogP0.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count16
Formal Charge0
Complexity320
SMILES
CS(=O)(=O)OCCCCCCOS(=O)(=O)C
InChI
InChI=1S/C8H18O6S2/c1-15(9,10)13-7-5-3-4-6-8-14-16(2,11)12/h3-8H2,1-2H3
InChIKey
WZOJEWBBWCYINS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,6-Hexanediol, dimethanesulfonate
CAS: 4239-24-1
CID: 145735
Formula: C8H18O6S2
MW: 274.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight274.4
XLogP30.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass274.05448064
Monoisotopic Mass274.05448064
Topological Polar Surface Area104 Ų
Heavy Atom Count16
Formal Charge0
Complexity320
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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