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LUF7244

CAT: 0804-HY-137986Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137986Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LUF7244 is a selective allosteric modulator of Kv11.1 channels. LUF7244 inhibits early afterdepolarizations. LUF7244 can be used for anti-arrhythmia research[1].
CAS Number
1821638-43-0
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/luf7244.html
Purity
99.70
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=CC=CC(Cl)=C3)=O)C=C2
Molecular Formula
C20H15ClN2O3
Molecular Weight
366.80
References & Citations
[1]Qile M, et, al. LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model. Br J Pharmacol. 2019 Oct;176 (19) :3871-3885.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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