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Dephospho-CoA

CAT: 0804-HY-137899Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137899Size:5 mg
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Description
Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed by GTP-dependent dephospho-CoA kinase (DPCK) to generate CoA. Dephospho-CoA completes the final synthesis step of CoA through phosphorylation reaction and participates in energy metabolism and cell signaling. Dephospho-CoA can be used in research including cancer (such as regulating cell proliferation) and metabolic diseases (such as mitochondrial dysfunction) [1][2].
CAS Number
[3633-59-8]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dephospho-coa.html
Purity
96.00
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2
Molecular Formula
C21H35N7O13P2S
Molecular Weight
687.55
References & Citations
[1]Gudkova D, et al. EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. FEBS Lett. 2012 Oct 19;586 (20) :3590-5.|[2]Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10 (4) :e01146-19.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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