Dephospho-CoA

• Description:

  Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed by GTP-dependent dephospho-CoA kinase (DPCK) to generate CoA. Dephospho-CoA completes the final synthesis step of CoA through phosphorylation reaction and participates in energy metabolism and cell signaling. Dephospho-CoA can be used in research including cancer (such as regulating cell proliferation) and metabolic diseases (such as mitochondrial dysfunction) [1][2].

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/dephospho-coa.html

• Purity:

  96.00

• Solubility:

  H2O : 50 mg/mL (ultrasonic; warming)

• Smiles:

  O[C@H] ([C@@H]1O) [C@] (O[C@@H]1CO[P] (O[P] (OCC (C) (C) [C@@H] (O) C (NCCC (NCCS) =O) =O) (O) =O) (O) =O) ([H]) N2C3=NC=NC (N) =C3N=C2

• Molecular Formula:

  C21H35N7O13P2S

• Molecular Weight:

  687.55

• References & Citations:

  [1]Gudkova D, et al. EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. FEBS Lett. 2012 Oct 19;586 (20) :3590-5.|[2]Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10 (4) :e01146-19.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  3633-59-8