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EGFR-IN-16

CAT: 0804-HY-137786Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-137786Size:1 Each
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Description
EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively[1].
CAS Number
133550-22-8
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1)/C(C#N)=C/C(C=C2)=CC(O)=C2O
Molecular Formula
C16H11NO3
Molecular Weight
265.26
References & Citations
[1]Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46 (22) :4657-4668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2

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