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Dimethindene

CAT: 0804-HY-13710-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13710-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH) . Dimethindene can block K+ currents[1][2].
CAS Number
5636-83-9
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite; Histamine Receptor; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dimethindene.html
Purity
98.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3
Molecular Formula
C20H24N2
Molecular Weight
292.42
Precautions
H315, H319, H335
References & Citations
[1]Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20 (13) :2366-8.|[2]Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266 (1) :99-102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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