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CS1

CAT: 0804-HY-137005Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-137005Size:1 Each
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Description
CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].
CAS Number
1448009-94-6
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cs1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1O
Molecular Formula
C16H12O3
Molecular Weight
252.26
References & Citations
[1]Shen Y, et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014; 453 (3) :302-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Topo II

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