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Fusarochromanone

CAT: 0804-HY-136901-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136901-01Size:1 mg
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Description
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity[1]. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) [2].
CAS Number
802915-53-3
Product Name Alternative
FC-101
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fusarochromanone.html
Solubility
10 mM in DMSO
Smiles
O=C1CC(C)(C)OC2=CC=C(C(C[C@@H](N)CO)=O)C(N)=C12
Molecular Formula
C15H20N2O4
Molecular Weight
292.33
References & Citations
[1]Elahe Mahdavian, et al.Biological activities of fusarochromanone: a potent anti-cancer agent. BMC Res Notes. 2014 Sep 3;7:601.|[2]Ying Gu, et al.Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5. Oncotarget. 2015 Dec 8;6 (39) :42322-33.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

5-amino-6-[(3R)-3-amino-4-hydroxybutanoyl]-2,2-dimethyl-3H-chromen-4-one
CAS Number802915-53-3
PubChem CID363059
IUPAC Name5-amino-6-[(3R)-3-amino-4-hydroxybutanoyl]-2,2-dimethyl-3H-chromen-4-one
Molecular FormulaC15H20N2O4
Molecular Weight292.33
XLogP-0.1
Topological Polar Surface Area116
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity424
SMILES
CC1(CC(=O)C2=C(O1)C=CC(=C2N)C(=O)C[C@H](CO)N)C
InChI
InChI=1S/C15H20N2O4/c1-15(2)6-11(20)13-12(21-15)4-3-9(14(13)17)10(19)5-8(16)7-18/h3-4,8,18H,5-7,16-17H2,1-2H3/t8-/m1/s1
InChIKey
COSICWYFCAPPJB-MRVPVSSYSA-N
Chemical Structure
2D Structure
2D structure of 5-amino-6-[(3R)-3-amino-4-hydroxybutanoyl]-2,2-dimethyl-3H-chromen-4-one
CAS: 802915-53-3
CID: 363059
Formula: C15H20N2O4
MW: 292.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.33
XLogP3-0.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass292.14230712
Monoisotopic Mass292.14230712
Topological Polar Surface Area116 Ų
Heavy Atom Count21
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M33984-01Fusarochromanone
TRC-F865595-25MG(R)-Fusarochromanone

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