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CLEFMA

CAT: 0804-HY-136718-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136718-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].
CAS Number
1246964-32-8
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clefma.html
Purity
98.03
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C\C(N1C/C(C(/C(C1)=C/C2=CC=CC=C2Cl)=O)=C\C3=CC=CC=C3Cl)=O
Molecular Formula
C23H17Cl2NO4
Molecular Weight
442.29
Precautions
H302, H410
References & Citations
[1]Lagisetty P, et, al. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis (benzylidene) -4-piperidones. Bioorg Med Chem. 2010 Aug 15; 18 (16) :6109-20.|[2]Yadav VR, et, al. Preclinical evaluation of 4-[3,5-bis (2-chlorobenzylidene) -4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. Br J Pharmacol. 2013 Dec; 170 (7) : 1436-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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