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CEM114

CAT: 0804-HY-136572Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-136572Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2279062-54-1
UNSPSC Description
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Target Antigen
CRISPR/Cas9; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cem114.html
Solubility
10 mM in DMSO
Smiles
CC1=NOC(C)=C1C2=CC=C(C3=C2)N(C(CCC(C=C4)=CC(F)=C4OCC(N=N5)=CN5CCOCCOCCOCCNC(CCSCCC[C@H](/C=C(C[C@@H](C[C@@H]([C@](O[C@]6(C7=O)O)([H])[C@H](C[C@H]6C)OC)OC)C)\C)C(C[C@@H]([C@H]([C@H](OC([C@@](CCCC8)([H])N8C7=O)=O)/C(C)=C/[C@H](CC[C@H]9O)C[C@H]9OC)C)O)=O)=O)=N3)CCN%10CCOCC%10
Molecular Weight
1612.98
References & Citations
[1]Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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