Exemestane-d2

CAT: 0804-HY-13632SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13632SSize:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Exemestane-d2 is the deuterium labeled Exemestane. Exemestane (FCE 24304) is a selective, irreversible and orally active steroidal aromatase inhibitor with IC50s of 30 nM and 40 nM for human placental and rat ovarian aromatase, respectively. Exemestane can be used for hormone-dependent breast cancer research[1][2].
Product Name Alternative
FCE 24304-d2; EXE-d2
UNSPSC
12352211
Target
Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@]3([H])[C@](CC(C1=CC(C=C2)=O)=C)([H])[C@@]4([H])[C@](CC3)(C(C([2H])([2H])C4)=O)C
Molecular Formula
C20H22D2O2
Molecular Weight
298.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Di Salle, E., et al., Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol, 1994. 49 (4-6) : p. 289-94.; Miki, Y, et al. Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2004 Sep 1;10 (17) :5717-23.; Goss, P.E., et al., Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats. Clin Cancer Res, 2004. 10 (17) : p. 5717-23.; Zaccheo, T., D. Giudici, and E. Di Salle, Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats. J Steroid Biochem Mol Biol, 1993. 44 (4-6) : p. 677-80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1

Related Products

CatalogName
HY-13632S5Exemestane-13C, d2
HY-13632-01Exemestane
HY-13632R-01Exemestane (Standard)
HY-13632S1-01Exemestane-13C3
HY-13632S2Exemestane-d3
HY-13632S6Exemestane-d4
HY-W748956Exemestane-13C, d3
HY-13808917β-Hydroxy exemestane
HY-167845SExemestane-19-d3
HY-138089S17β-Hydroxy exemestane-d3

Alternative Products

CatalogName
ESS0188-01Exemestane-D2
sc-499281Exemestane-13C, d2
MBS576243-01Exemestane
TMIJ-0222-01Exemestane-d3
A10378-10Exemestane 10mg
A10378-50Exemestane 50mg

Popular Products