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Spisulosine

CAT: 0804-HY-13626Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13626Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells[1].
CAS Number
196497-48-0
Product Name Alternative
ES-285
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; PKC
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spisulosine.html
Purity
99.00
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
C[C@H](N)[C@H](O)CCCCCCCCCCCCCCC
Molecular Formula
C18H39NO
Molecular Weight
285.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584 (2-3) :237-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
PKCζ

Alternative Products

CatalogName
T9664-01Spisulosine

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