Diflomotecan

CAT: 0804-HY-13611Size: 1 EachDry Ice: NoHazardous: No

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Description

Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds[1][2].

CAS Number

220997-97-7

Product Name Alternative

BN 80915

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/diflomotecan.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1)C[C@](O)(CC)C2=C1C(N3CC4=CC5=CC(F)=C(F)C=C5N=C4C3=C2)=O

Molecular Formula

C21H16F2N2O4

Molecular Weight

398.36

References & Citations

[1]Kroep JR, et al. Diflomotecan, a promising homocamptothecin for cancer therapy. Expert Opin Investig Drugs. 2009;18 (1) :69-75.|[2]Gelderblom H, et al. Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors. Clin Cancer Res. 2003;9 (11) :4101-4107.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

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