Tetrazine-PEG4-oxyamine (hydrochloride)

Tetrazine-PEG4-oxyamine (hydrochloride)

• UNSPSC Description: Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-PEG4-oxyamine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tetrazine-peg4-oxyamine-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: NOCC(NCCOCCOCCOCCOCCC(NCC(C=C1)=CC=C1C2=NN=CN=N2)=O)=O.Cl
• Molecular Weight: 544.00
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported