Methyltetrazine-SS-NHS

CAT:

804-HY-136033

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UNSPSC Description: Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Target Antigen: ADC Linker
Type: ADC Related
Related Pathways: Antibody-drug Conjugate/ADC Related
Applications: Cancer-programmed cell death
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/methyltetrazine-ss-nhs.html
Solubility: 10 mM in DMSO
Smiles: CC1=NN=C(C2=CC=C(CNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)C=C2)N=N1
Molecular Weight: 490.56
References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-136033	Methyltetrazine-SS-NHS
HY-133466-01	Methyltetrazine-PEG4-SS-NHS ester
HY-133466-02	Methyltetrazine-PEG4-SS-NHS ester
HY-130943	Methyltetrazine-PEG4-SS-PEG4-methyltetrazine
HY-136035	Methyltetrazine-SS-PEG4-Biotin
HY-141269-05	Methyltetrazine-PEG5-NHS ester
HY-141269-03	Methyltetrazine-PEG5-NHS ester
HY-151758	Methyltetrazine-PEG12-NHS ester
HY-141272-02	Methyltetrazine-PEG24-NHS ester
HY-141272-01	Methyltetrazine-PEG24-NHS ester

Cat	Name
T18358-1mg	Methyltetrazine-SS-NHS
T18358-5mg	Methyltetrazine-SS-NHS
T18358-1g	Methyltetrazine-SS-NHS
T18358-50mg	Methyltetrazine-SS-NHS
T18358-10mg	Methyltetrazine-SS-NHS
T18351-50mg	Methyltetrazine-PEG4-SS-NHS ester
T18351-10mg	Methyltetrazine-PEG4-SS-NHS ester
T18351-1mg	Methyltetrazine-PEG4-SS-NHS ester
T18351-1g	Methyltetrazine-PEG4-SS-NHS ester
T18351-5mg	Methyltetrazine-PEG4-SS-NHS ester