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LY393615

CAT: 0804-HY-135478Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135478Size:1 Each
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Description
LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research[1].
CAS Number
325819-97-4
Product Name Alternative
NCC1048
UNSPSC
12352005
Target
Calcium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly393615.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C2(C3=CC=C(F)C=C3)CCC(CNCCCC)O2)C=C1.[H]Cl
Molecular Formula
C21H26ClF2NO
Molecular Weight
381.89
References & Citations
[1]O'Neill MJ, et.al. LY393615, a novel neuronal Ca (2+) and Na (+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia. Brain Res. 2001 Jan 5;888 (1) :138-149.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P/Q-type calcium channel

Alternative Products

CatalogName
MBS5820289LY393615

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