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Norverapamil

CAT: 0804-HY-135328Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135328Size:1 Each
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Description
Norverapamil ((±) -Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].
CAS Number
67018-85-3
Product Name Alternative
(±) -Norverapamil; D591
UNSPSC
12352005
Hazard Statement
H301
Target
Calcium Channel; Drug Metabolite; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/norverapamil.html
Solubility
10 mM in DMSO
Smiles
N#CC(C(C)C)(CCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C(OC)C(OC)=C2
Molecular Formula
C26H36N2O4
Molecular Weight
440.58
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210 (3) :456-66.|[2]Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293 (2) :376-82.|[3]Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50 (3-4) :290-302.|[4]Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34 (3-4) :163-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
L-type calcium channel

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