Roxadustat-d5

• Description:

  Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312+H332, H315, H319

• Target:

  Ferroptosis; HIF/HIF Prolyl-Hydroxylase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  98.80

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])C=C2)=O

• Molecular Formula:

  C19H11D5N2O5

• Molecular Weight:

  357.37

• Precautions:

  H302+H312+H332, H315, H319

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Provenzano R, et al. Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving MaintenanceHemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study. Am J Kidney Dis. 2016 Jun;67 (6) :912-24.|[3]Wu K, et al. Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016 Feb 1;1632:19-26.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [2043026-13-5]