Bofutrelvir

CAT: 0804-HY-133894Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-133894Size:1 mg

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Description

Bofutrelvir (FB2001) is a SARS-CoV-2 main protease Mpro inhibitor with an IC50 value of 53 nM and an EC50 value of 0.53 μM. Bofutrelvir exhibits potent antiviral efficacy against several current SARS-CoV-2 variants with EC50 values of 0.26-0.42 μM. Bofutrelvir has an additive antiviral effect when combined with Remdesivir[2].

CAS Number

2103278-86-8

Product Name Alternative

FB2001

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bofutrelvir.html

Purity

96.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(N1)=CC2=C1C=CC=C2)N[C@@H](CC3CCCCC3)C(N[C@H](C=O)C[C@H]4C(NCC4)=O)=O

Molecular Formula

C25H32N4O4

Molecular Weight

452.55

References & Citations

[1]Ullrich S, Nitsche C. The SARS-CoV-2 main protease as drug target. Bioorg Med Chem Lett. 2020 Sep 1;30 (17) :127377.|[2]Shang W, et al. In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2. Antiviral Res. 2022 Dec;208:105450.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 3

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