Propargyl-O-C1-amido-PEG3-C2-NHS ester

Propargyl-O-C1-amido-PEG3-C2-NHS ester

• CAS Number: 2101206-78-2
• UNSPSC Description: Propargyl-O-C1-amido-PEG3-C2-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-O-C1-amido-PEG3-C2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/propargyl-o-c1-amido-peg3-c2-nhs-ester.html
• Solubility: 10 mM in DMSO
• Smiles: C#CCOCC(NCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O
• Molecular Weight: 414.41
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported