JNK-IN-8 (GMP)

JNK-IN-8 (GMP)

• CAS Number: 1410880-22-6
• UNSPSC Description: JNK-IN-8 (JNK Inhibitor XVI) (GMP) is JNK-IN-8 (HY-13319) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. JNK-IN-8 is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1].
• Target Antigen: JNK
• Type: GMP Small Molecules
• Related Pathways: MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/jnk-in-8-gmp.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3
• Molecular Weight: 507.59
• References & Citations: [1]Bengoa-Vergniory N, et al. A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells. Stem Cells. 2014 Dec;32(12):3196-208. |[2]Xiao X, et al. Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov. 2019 Jan 8;5:2.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported