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Montelukast-d6

CAT: 0804-HY-13315SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13315SSize:1 mg
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Description
Montelukast-d6 is the deuterium labeled Montelukast (sodium) . Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1) . Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].
CAS Number
1093746-29-2
Product Name Alternative
MK0476-d6 (free acid)
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Leukotriene Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C(O)CC1(CS[C@@H](C2=CC=CC(/C=C/C3=NC4=CC(Cl)=CC=C4C=C3)=C2)CCC5=CC=CC=C5C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])CC1
Molecular Formula
C35H30D6ClNO3S
Molecular Weight
592.22
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pu S, et, al. Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury. Front Pharmacol. 2019 Sep 18; 10:1070.; William RHJ, et, al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 2002 Jan 1; 165 (1) : 108-16.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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