FAICAR

• Description:

  FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and substrate for the IMP cyclohydrolase of ATIC from Cryptococcus neoformans. FAICAR is a key intermediate in the de novo purine biosynthesis pathway. FAICAR can be used in the research of diseases associated with Cryptococcus neoformans infection[1][2].

• Product Name Alternative:

  5-Formamidoimidazole-4-carboxamide ribotide

• UNSPSC:

  12352005

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/faicar.html

• Purity:

  85.81

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N

• Molecular Formula:

  C10H15N4O9P

• Molecular Weight:

  366.22

• References & Citations:

  [1]E Szabados, et al. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem|[2]Wizrah MSI, et al. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022 Oct;298 (10) :102453.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [13018-54-7]