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FAICAR

CAT: 0804-HY-133157Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133157Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and substrate for the IMP cyclohydrolase of ATIC from Cryptococcus neoformans. FAICAR is a key intermediate in the de novo purine biosynthesis pathway. FAICAR can be used in the research of diseases associated with Cryptococcus neoformans infection[1][2].
CAS Number
13018-54-7
Product Name Alternative
5-Formamidoimidazole-4-carboxamide ribotide
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/faicar.html
Purity
85.81
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N
Molecular Formula
C10H15N4O9P
Molecular Weight
366.22
References & Citations
[1]E Szabados, et al. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem|[2]Wizrah MSI, et al. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022 Oct;298 (10) :102453.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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BA4039-1FAICAR
TRC-F101065-5MGFAICAR (>80%)

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