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FM26

CAT: 0804-HY-133128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133128Size:1 Each
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Description
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].
CAS Number
2407981-35-3
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fm26.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(NCC2=C(C3=CNC=C3)ON=C2C4=C(C(F)(F)F)C=CC=C4Cl)C=C1
Molecular Formula
C22H15ClF3N3O3
Molecular Weight
461.82
References & Citations
[1]Meijer FA, et al.Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists.J Med Chem. 2020 Jan 9;63 (1) :241-259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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