ADAM8-IN-1

• UNSPSC Description:

  ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.

• Target Antigen:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/adam8-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCCC[C@@H](NS(=O)(C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1)=O)C(NO)=O)C3=CC=CC(C(NCCC[C@@H](NS(=O)(C4=CC=C(OCC5=CC(Br)=CC(Br)=C5)C=C4)=O)C(NO)=O)=O)=C3

• Molecular Weight:

  1232.60

• References & Citations:

  [1]Cuffaro D, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med. Chem. Lett. 2021, 12, 11, 1787–1793.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2758892-64-5