Nedosiran

CAT: 0804-HY-132606-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-132606-01Size:1 mg

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Description

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH) . Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD) . Nedosiran is a GalNAc-dsRNA conjugate[1][2][3].

CAS Number

2266591-83-5

Product Name Alternative

DCR-PHXC

UNSPSC

12352208

Target

Lactate Dehydrogenase; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nedosiran.html

Solubility

10 mM in H2O

Smiles

[Nedosiran]

Molecular Formula

C662H865F19N231O413P57S6

Molecular Weight

20985.12

References & Citations

[1]Kevin Shee, et al. Nedosiran Dramatically Reduces Serum Oxalate in Dialysis-Dependent Primary Hyperoxaluria 1: A Compassionate Use Case Report. Urology.2021 Oct;156:e147-e149.|[2]Gema Ariceta, et al. Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep. 2021 Feb 3;6 (4) :1088-1098. |[3]Thomas A Forbes, et al. Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria. Br J Clin Pharmacol. 2021 May 22.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Launched

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