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2'MeO6MF

CAT: 0804-HY-131997Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131997Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
CAS Number
89112-85-6
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-meo6mf.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=CC=C2OC)OC3=CC=C(C)C=C13
Molecular Formula
C17H14O3
Molecular Weight
266.29
References & Citations
[1]Karim N, et, al. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA (A) receptors. Br J Pharmacol. 2012 Feb;165 (4) :880-96.|[2]Clarkson AN, et, al. The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. J Cereb Blood Flow Metab. 2019 Jul;39 (7) :1266-1282.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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