RJW100

• Description:

  RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2].

• UNSPSC:

  12352005

• Target:

  MicroRNA

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/rjw100.html

• Purity:

  99.93

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1CC[C@@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@@]12[H]

• Molecular Formula:

  C28H34O

• Molecular Weight:

  386.58

• References & Citations:

  [1]Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2) . J Med Chem. 2011 Apr 14;54 (7) :2266-81.|[2]Yuxia Zhang, et al. Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416 (1-2) :135-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1276664-20-0]