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MGS0274

CAT: 0804-HY-131336Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131336Size:1 Each
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Description
MGS0274, an ester-based lipophilic proagent of a metabotropic glutamate (mGlu) 2 and mGlu3 receptor agonist MGS0008, shows improved oral bioavailability. MGS0274 has the potential for the research of schizophrenia[1][2].
CAS Number
1501974-69-1
UNSPSC
12352211
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mgs0274.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]1(N)[C@]2([H])[C@@H](C(O[C@@H](OC(O[C@H]3[C@H](C(C)C)CC[C@@H](C)C3)=O)C)=O)[C@]2([H])C[C@@H]1F)O
Molecular Formula
C21H32FNO7
Molecular Weight
429.48
References & Citations
[1]Urabe H, et al. Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability [published online ahead of print, 2020 Jul 5]. Eur J Med Chem. 2020;203:112521.|[2]Kinoshita K, et al. Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia. Pharmacol Res Perspect. 2019;7 (5) :e00520. Published 2019 Sep 13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3

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