Curdlan

CAT: 0804-HY-131166Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-131166Size:500 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Curdlan is a polysaccharide found in bacteria, consisting of a glucose homopolymer with β-1,3-glycosidic linkages[1]. Curdlan can be recognized by Dectin-1 (a C-type lectin receptor), inducing immune responses in tissue mast cells and enhancing dendritic cell effects in tumor immunity. Curdlan holds potential for research in cancer and immune-inflammatory diseases[1][2][3].

CAS Number

54724-00-4

UNSPSC

12352211

Target

Bacterial; C-type Lectin-like Receptors (CTLRs) ; NO Synthase; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/curdlan.html

Purity

98.5

Solubility

0.1 M NaOH : 1 mg/mL (ultrasonic; adjust pH to 12 with NaOH) |DMSO : 10 mg/mL (ultrasonic)

Smiles

OC[C@H]1O[C@@H](C)[C@H](O)C(OC)[C@@H]1O.[n]

Molecular Formula

(C6H10O5) n

References & Citations

[1]Masanori Miwa, et al. Food Applications of Curdlan. Food Hydrocolloids pp 119-124.|[2]Kim HS, et al. Curdlan activates dendritic cells through dectin-1 and toll-like receptor 4 signaling. Int Immunopharmacol. 2016 Oct;39:71-78.|[3]Żelechowska P, et al. Curdlan stimulates tissue mast cells to synthesize pro-inflammatory mediators, generate ROS, and migrate via Dectin-1 receptor. Cell Immunol. 2020 May;351:104079.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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Curdlan

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