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γ-Amanitin

CAT: 0804-HY-131081Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131081Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells[1][2][3].
CAS Number
21150-23-2
UNSPSC
12352203
Target
ADC Payload; DNA/RNA Synthesis
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/γ-amanitin.html
Purity
90.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(N)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O
Molecular Formula
C39H54N10O13S
Molecular Weight
902.97
References & Citations
[1]He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. |[2]Gong M, et al. Amanitin-induced variable cytotoxicity in various cell lines is mediated by the different expression levels of OATP1B3. Food Chem Toxicol. 2024 Jun;188:114665. |[3]Garcia J, et al. Amanita phalloides poisoning: Mechanisms of toxicity and treatment. Food Chem Toxicol. 2015 Dec;86:41-55.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Traditional Cytotoxic Agents

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