Tetrazine-PEG4-SS-Py

Tetrazine-PEG4-SS-Py

• UNSPSC Description: Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-PEG4-SS-Py is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tetrazine-peg4-ss-py.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CCOCCOCCOCCOCCNC(CCSSC1=CC=CC=N1)=O)NCC2=CC=C(C3=NN=CN=N3)C=C2
• Molecular Weight: 631.77
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported