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HPB

CAT: 0804-HY-130493-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130493-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].
CAS Number
1800066-24-3
Product Name Alternative
HDAC6 inhibitor HPB
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpb.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N(CC1=CC=C(C(NO)=O)C=C1)CCO)CC2=CC=CC=C2
Molecular Formula
C18H20N2O4
Molecular Weight
328.36
References & Citations
[1]Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114 (51) :13459-13464.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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