HPB

• Description :

  HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].

• Product Name Alternative :

  HDAC6 inhibitor HPB

• UNSPSC :

  12352005

• Target :

  HDAC

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hpb.html

• Purity :

  99.11

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N(CC1=CC=C(C(NO)=O)C=C1)CCO)CC2=CC=CC=C2

• Molecular Formula :

  C18H20N2O4

• Molecular Weight :

  328.36

• References & Citations :

  [1]Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114 (51) :13459-13464.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC6

• CAS Number :

  [1800066-24-3]